Osmosis Jones

August 10, 2001
Directed by
Peter Farrelly

A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

cold

flu

lethal virus

construction worker

Last Updated: November 7, 2025

Cast

Chris Rock as Osmosis Jones (voice)

Chris Rock

Osmosis Jones (voice)

Laurence Fishburne as Thrax (voice)

Laurence Fishburne

Thrax (voice)

David Hyde Pierce as Drix (voice)

David Hyde Pierce

Drix (voice)

Brandy Norwood as Leah (voice)

Brandy Norwood

Leah (voice)

Bill Murray as Frank Detorre

Bill Murray

Frank Detorre

Molly Shannon as Mrs. Boyd

Molly Shannon

Mrs. Boyd

William Shatner as Mayor Phlegmming (voice)

William Shatner

Mayor Phlegmming (voice)

Ron Howard as Tom Colonic (voice)

Ron Howard

Tom Colonic (voice)

Sherry Lynn as (voice)

Sherry Lynn

(voice)

Mickie McGowan as Additional Character Voice (voice)

Mickie McGowan

Additional Character Voice (voice)

Chris Elliott as Bob

Chris Elliott

Bob

Elena Franklin as Shane Detorre

Elena Franklin

Shane Detorre

Kid Rock as Kidney Rock

Kid Rock

Kidney Rock

Uncle Kracker

Kidney Rock (voice)

Carlos Alazraqui as Additional Character Voices (voice)

Carlos Alazraqui

Additional Character Voices (voice)

Osmosis Jones Trailer 1 (2001)

Osmosis Jones Trailer 1 (2001)

Osmosis Jones - The Making Of

Osmosis Jones - The Making Of

The Voices of Osmosis Jones (Part 2)

The Voices of Osmosis Jones (Part 2)

The Voices of Osmosis Jones (Part 1)

The Voices of Osmosis Jones (Part 1)

Image Gallery

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