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Science Fiction

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Science Fiction

Annihilation

February 22, 2018
Directed by
Alex Garland

A biologist signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply.

depression

florida

quarantine

coma

based on novel or book

+34 more

Last Updated: November 2, 2025

Cast

Natalie Portman as Lena

Natalie Portman

Lena

Jennifer Jason Leigh as Dr Ventress

Jennifer Jason Leigh

Dr Ventress

Gina Rodriguez as Anya Thorensen

Gina Rodriguez

Anya Thorensen

Tessa Thompson as Josie Radek

Tessa Thompson

Josie Radek

Tuva Novotny as Cass Sheppard

Tuva Novotny

Cass Sheppard

Oscar Isaac as Kane

Oscar Isaac

Kane

Benedict Wong as Lomax

Benedict Wong

Lomax

Sonoya Mizuno as Humanoid / Katie (Med Student)

Sonoya Mizuno

Humanoid / Katie (Med Student)

David Gyasi as Daniel

David Gyasi

Daniel

John Schwab as Paramedic

John Schwab

Paramedic

Sammy Hayman as Mayer

Sammy Hayman

Mayer

Josh Danford as Shelley

Josh Danford

Shelley

Kristen McGarrity as Lena Double

Kristen McGarrity

Lena Double

Kumud Pant as Scientist

Kumud Pant

Scientist

Honey Holmes as Scientist (uncredited)

Honey Holmes

Scientist (uncredited)

Official Trailer

Official Trailer

Alex Garland discusses ANNIHILATION's psychedelic ending

Alex Garland discusses ANNIHILATION's psychedelic ending

From Page to Screen Featurette

From Page to Screen Featurette

Story Featurette

Story Featurette

ANNIHILATION's mind-bending adaptation

ANNIHILATION's mind-bending adaptation

Cast Featurette

Cast Featurette

The Shimmer Featurette

The Shimmer Featurette

Image Gallery

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